Hyperbranched amphiphilic polymer with folate mediated targeting property
Related Experiment Video
Updated: Jun 12, 2026

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
Published on: August 6, 2019
Lei Zhang1, Chao-Hua Hu, Si-Xue Cheng
1Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
Abstract:
Hyperbranched amphiphilic polymer PG6-PLA-PEG was synthesized through grafting hydrophobic poly(D,L-lactide) (PLA) segments and hydrophilic poly(ethylene glycol) (PEG) blocks to hydrophilic hyperbranched polyglycerol core (PG6), subsequently. To achieve cell targeting property, folic acid (FA) was further incorporated to the hyperbranched polymer to obtain PG6-PLA-PEG-FA. The polymers were characterized by (1)H NMR, UV-vis spectroscopy and combined size-exclusion chromatography and multiangle laser light scattering (SEC-MALLS) analysis. Due to the amphiphilicity, PG6-PLA-PEG and PG6-PLA-PEG-FA could self-assemble to form nanoparticles in aqueous solutions. Antineoplastic drug, paclitaxel (PTX), was encapsulated into the nanoparticles. The nanoparticles were observed by transmission electron microscopy (TEM). The targeting property of PG6-PLA-PEG-FA was evaluated in vitro. The results showed that the PTX loaded PG6-PLA-PEG-FA nanoparticles exhibited enhanced inhibition on folate receptor positive tumor cells due to the folate mediated targeting.
More Related Videos
10:53Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
14:20Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Site-Targeted
Polymer Classification: Architecture
Cationic Chain-Growth Polymerization: Mechanism
Anionic Chain-Growth Polymerization: Overview