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Updated: Jun 12, 2026

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
Published on: January 12, 2021
B cell repertoire and ageing
Deborah K Dunn-Walters1, Alexander A Ademokun
1Department of Immunobiology, King's College London School of Medicine, Guy's Campus, London SE1 9RT, UK. Deborah.dunn-walters@kcl.ac.uk
Abstract:
A diverse B cell repertoire is essential for an effective immune response. Not only to provide a variety of antibodies to recognise the multiplicity of likely pathogen challenge, but also because B cells are important regulators of the immune response. In addition to their excellent capabilities as antigen presenting and activating cells, recent work shows that some subpopulations of B cells can have suppressive functions. The diversity of the B cell population as a whole decreases with age, and is associated with ill health. Whether decreased diversity is a feature of all B cells or a reflection of altered subpopulations is not clear, since different subsets of B cells have different functions and their repertoires are shaped by different selection pressures.
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