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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Related Experiment Video

Updated: Jun 12, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Micro-RNAs and breast cancer.

John Le Quesne1, Carlos Caldas

  • 1Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

Molecular Oncology
|June 12, 2010
PubMed
Summary
This summary is machine-generated.

Micro-RNAs (miRs) regulate gene expression and are crucial for normal breast development. These small non-coding RNAs also play significant roles in breast cancer, acting as both oncogenes and tumor suppressors.

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Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

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Related Experiment Videos

Last Updated: Jun 12, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

Published on: May 16, 2012

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Micro-RNAs (miRs) are small non-coding RNA molecules that regulate gene expression post-transcriptionally.
  • miRs are essential for normal physiological processes, including cell differentiation and determination.
  • Dysregulation of miRs is implicated in various diseases, including cancer.

Purpose of the Study:

  • To review the known biology of miRs in the normal human breast.
  • To discuss the emerging roles of miRs in the development and progression of breast cancer.
  • To highlight the dual function of miRs as oncogenes and tumor suppressors in breast cancer.

Main Methods:

  • Literature review of studies on miR biology and function.
  • Analysis of miR involvement in normal breast tissue development.
  • Examination of miR dysregulation in breast cancer pathogenesis.

Main Results:

  • miRs are integral to normal breast cell differentiation and tissue organization.
  • Aberrant miR expression is a common feature of breast tumors.
  • Specific miRs can promote or inhibit tumor growth, highlighting their complex roles.

Conclusions:

  • miRs are critical regulators of breast biology with significant implications for cancer.
  • Understanding miR function in breast cancer offers potential for novel therapeutic strategies.
  • Further research into miR mechanisms is warranted for clinical applications.