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[Sensitivity of Pseudomonas to currently used antibacterial drugs]
Abstract:
Sensitivity of 184 strains of four Preudomonas species that are of importance from the medical viewpoint was studied. It was shown that all the studied strains were resistant to cefazolin and ampicillin. Sulfomonomethoxine was active only against P. mallei. Gentamicin inhibited the growth of all the strains of P. mallei and 60 per cent of the strains of P. aeruginosa. Among the four studied strains, the causative agent of glanders was the least resistant to the chemotherapeutic drugs. Eleven out of the 16 studied drugs were active against P. mallei. The strains of P. pseudomallei, the organism causing melioidosis were sensitive to 6 drugs: ceftazidime, imipenem, doxycycline, minocycline, chloramphenicol and biseptol. The dime, ceftriaxone, cefsulodin, cefoperazone, cefotaxime, piperacillin and imipenem. The strains of P. cepacia were the most resistant to all the chemotherapeutic drugs studied and only biseptol was active in the concentrations attained in blood of patients (MIC50 12.5 mg/l). 10 to 70 per cent of the strains were sensitive to ceftazidime, imipenem, doxycycline, minocycline and rifampicin. Therefore, imipenem and ceftazidime were the most active drugs with respect to the causative agents of pseudomonoses. Biseptol, doxycycline and minocycline are also worthy note.
Insights
This study evaluated the antibiotic sensitivity of four medically important Pseudomonas species. Imipenem and ceftazidime demonstrated the most activity against causative agents of pseudomonoses.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Pseudomonas species are significant pathogens with varying antimicrobial susceptibility.
- Understanding resistance patterns is crucial for effective treatment of pseudomonoses.
Purpose of the Study:
- To assess the in vitro sensitivity of 184 strains from four medically relevant Pseudomonas species to 16 different chemotherapeutic drugs.
- To identify effective antimicrobial agents against specific Pseudomonas species, including P. mallei, P. pseudomallei, P. aeruginosa, and P. cepacia.
Main Methods:
- Antimicrobial sensitivity testing was performed on 184 clinical isolates of four Pseudomonas species.
- Minimum Inhibitory Concentrations (MICs) were determined for 16 different chemotherapeutic agents.
Main Results:
- All strains were resistant to cefazolin and ampicillin.
- P. mallei showed the highest sensitivity, with 11 drugs active against it. P. pseudomallei was sensitive to ceftazidime, imipenem, doxycycline, minocycline, chloramphenicol, and biseptol.
- P. cepacia exhibited the highest resistance, with only biseptol showing activity at clinically relevant concentrations. Imipenem and ceftazidime were most active against Pseudomonas agents overall.
Conclusions:
- Imipenem and ceftazidime are recommended as the most effective agents against the studied Pseudomonas species.
- Biseptol, doxycycline, and minocycline also show potential utility in treating infections caused by these pathogens.