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Related Concept Videos

What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
Transgenic Plants02:50

Transgenic Plants

Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
Transgenic Organisms00:53

Transgenic Organisms

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Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
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Gene doping: the hype and the harm.

Trudy A McKanna1, Helga V Toriello

  • 1Spectrum Health Genetic Services, Grand Rapids, MI 49503, USA. trudy.mckanna@spectrum-health.org

Pediatric Clinics of North America
|June 12, 2010
PubMed
Summary

Gene doping, the misuse of gene therapy for athletic advantage, involves altering gene expression for physical enhancement. While theoretical, it poses significant ethical and medical challenges for sports and genetics.

Area of Science:

  • Sports Science
  • Genetics
  • Bioethics

Background:

  • Gene therapy techniques are being explored for potential misuse in sports.
  • Performance enhancement through genetic modification is a growing concern.

Purpose of the Study:

  • To define gene doping and its potential mechanisms.
  • To explore the implications of gene doping in sports and medicine.

Main Methods:

  • Conceptual analysis of gene therapy applications.
  • Review of potential gene targets like insulin-like growth factor 1 (IGF-1).

Main Results:

  • Gene doping could enhance muscle mass and power through gene overexpression.
  • Insulin-like growth factor 1 (IGF-1) is a key potential target.

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Conclusions:

  • Gene doping, though theoretical, presents significant ethical and medical challenges.
  • The implications for sports, health, and medical genetics require careful consideration.