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Updated: Jun 12, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
Accounting for response misclassification and covariate measurement error improves power and reduces bias in
Dunlei Cheng1, Adam J Branscum, James D Stamey
1Institute for Health Care Research and Improvement, Dallas, TX 75206, USA. dunleic@baylorhealth.edu <dunleic@baylorhealth.edu>
Purpose:
To quantify the impact of ignoring misclassification of a response variable and measurement error in a covariate on statistical power, and to develop software for sample size and power analysis that accounts for these flaws in epidemiologic data.
Methods:
A Monte Carlo simulation-based procedure is developed to illustrate the differences in design requirements and inferences between analytic methods that properly account for misclassification and measurement error to those that do not in regression models for cross-sectional and cohort data.
Results:
We found that failure to account for these flaws in epidemiologic data can lead to a substantial reduction in statistical power, over 25% in some cases. The proposed method substantially reduced bias by up to a ten-fold margin compared to naive estimates obtained by ignoring misclassification and mismeasurement.
Conclusions:
We recommend as routine practice that researchers account for errors in measurement of both response and covariate data when determining sample size, performing power calculations, or analyzing data from epidemiological studies.
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