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[Antibiotic therapy of acute dysentery in children with immunologic deficiency conditions]
Insights
Children with secondary immune deficiency experienced longer recovery times from dysentery. Combining antibiotics with prodigiozan and lysozyme normalized recovery periods in these patients.
Area of Science:
- Pediatrics
- Infectious Diseases
- Immunology
Background:
- Dysentery is a significant childhood infection.
- Immune deficiency can complicate infectious disease recovery.
- Understanding immune status is crucial for effective treatment.
Purpose of the Study:
- To investigate the impact of secondary immune deficiency on dysentery recovery.
- To evaluate the efficacy of combined antibiotic therapy with immunomodulators.
Main Methods:
- A cohort of 100 children with acute Sonnei and flexneri dysentery was studied.
- Children were categorized into physiological immunity and secondary immune deficiency groups.
- Treatment involved aminoglycoside antibiotics, prodigiozan, and lysozyme.
Main Results:
- Children with immune deficiency had a 5.2-day longer recovery time.
- Combined therapy (antibiotics, prodigiozan, lysozyme) reduced recovery time in immune-deficient children.
- This combination normalized recovery to levels seen in children with normal immunity.
Conclusions:
- Secondary immune deficiency prolongs dysentery recovery in children.
- Combined antibiotic, prodigiozan, and lysozyme therapy is effective for dysentery in immune-deficient children.
- This treatment approach is recommended for all dysentery forms in this patient group.
Abstract:
One hundred children with acute Sonnei and flexneri dysentery were followed up with respect to the infection process and main immunity indices. In 32 children the immunity indices were physiological (group 1) and in 68 children secondary immune deficiency was observed (group 2). The children were treated with aminoglycoside antibiotics and prodigiozan and it was stated that the time of recovery in the children with immune deficiency was longer by 5.2 days as compared to that in the children without immune deficiency. In the children with immune deficiency the combined use of one of the aminoglycosides, prodigiozan and lysozyme, led to a reduction of the host immunological reactivity and recovery within the same periods as those recorded for children with the physiological immunity status. It is recommended to use the antibiotic combination with prodigiozan and lysozyme in the treatment of all the forms of dysentery in children with secondary immune deficiency.