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A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
Published on: July 2, 2014
3-D cytoarchitectonic parcellation of human orbitofrontal cortex correlation with postmortem MRI
Harry B M Uylings1, Ernesto J Sanz-Arigita, Koos de Vos
1Department of Anatomy & Neuroscience, VU University Medical Center, Graduate School Neurosciences Amsterdam, Amsterdam, The Netherlands. hbm.uylings@vumc.nl
Psychiatry Research
|June 12, 2010
Summary
This study precisely maps the human orbitofrontal cortex (OFC) using cytoarchitectonic analysis. It provides a detailed parcellation of the OFC, including Brodmann
Area of Science:
- Neuroanatomy
- Human Brain Mapping
Background:
- The orbitofrontal cortex (OFC) is crucial for cognitive functions and implicated in psychiatric disorders.
- Existing parcellations of the OFC lack precise cytoarchitectonic definitions, hindering consistent application in research.
Purpose of the Study:
- To provide a detailed cytoarchitectonic parcellation of the human orbitofrontal cortex (OFC).
- To establish reproducible boundaries for OFC areas applicable to neuroimaging studies.
Main Methods:
- Microscopic examination of cytoarchitecture in postmortem human brain sections.
- Correlative analysis with magnetic resonance imaging (MRI) of the same brains.
- Independent verification of delineated borders by two neuroanatomists.
Main Results:
- Brodmann's areas 47 and 11 were identified within the human OFC.
- Area 47 was subdivided into three medial and two lateral subareas.
- An anterior-posterior cytoarchitectonic gradient was observed in areas 11 and 47.
Conclusions:
- This study presents a refined cytoarchitectonic map of the human OFC.
- The proposed parcellation provides a standardized framework for OFC research, particularly in neuroimaging.
