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Synthesis and schistosomicidal activity of 4-methyl-5-(aryl vinyl)-1,2-dithiole-3-thiones
F Abdaly1, C Vaccher, P Berthelot
1Laboratoire de Pharmacie Chimique, Faculté de Pharmacie, Université de Lille, France.
Farmaco (Societa Chimica Italiana : 1989)
|January 1, 1991
Abstract:
The synthesis of vinylogous of 1,2-dithiole-3-thione is described. The activity in experimental schistosomiasis (schistosomicidal activity) was tested with mice infected with Schistosoma mansoni. The reference compound was 4-methyl-5-(pyrazinyl)-1,2-dithiole-3-thione (oltipraz).