Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Birthweight phenotype genotype mismatch in cardiometabolic programming.

Communications medicine·2026
Same author

Association of Combined Lifestyle Behaviors With Healthspan in Older Adults.

Journal of the American Geriatrics Society·2026
Same author

Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.

European heart journal·2026
Same author

Reassessing Ferritin Levels in Healthy Older Adults: Updated Reference Ranges and Associated Health Outcomes.

Archives of pathology & laboratory medicine·2026
Same author

Higher legume and cruciferous vegetable intakes are associated with lower cardiometabolic risk in young adults: a cross-sectional study.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2026
Same author

Protective potential of minimally processed, plant-derived foods against steatotic liver disease in early adulthood.

Clinical nutrition ESPEN·2026

Related Experiment Video

Updated: Jun 12, 2026

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
13:05

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids

Published on: June 28, 2019

The omega-3 fatty acids EPA and DHA decrease plasma F(2)-isoprostanes: Results from two placebo-controlled

Emilie Mas1, Richard J Woodman, Valerie Burke

  • 1University of Western Australia, Perth, WA, Australia. emilie.mas@uwa.edu.au

Free Radical Research
|June 15, 2010
PubMed
Summary

Omega-3 fatty acids, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) reduce in vivo oxidant stress. Supplementation with EPA or DHA significantly lowered plasma F(2)-isoprostanes, a marker of oxidative stress, in human studies.

More Related Videos

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
07:36

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

Related Experiment Videos

Last Updated: Jun 12, 2026

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
13:05

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids

Published on: June 28, 2019

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
07:36

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

Area of Science:

  • Cardiovascular Health
  • Nutritional Science
  • Biochemistry

Background:

  • Omega-3 fatty acids (EPA and DHA) are known for cardiovascular benefits.
  • Concerns exist regarding omega-3s potentially increasing lipid peroxidation.
  • Previous studies indicated reduced urinary F(2)-isoprostanes with omega-3 supplementation.

Purpose of the Study:

  • To investigate the effect of EPA and DHA supplementation on plasma F(2)-isoprostanes.
  • To determine if omega-3 fatty acids influence in vivo oxidant stress markers.

Main Methods:

  • Two 6-week placebo-controlled intervention studies (Study A and Study B) were conducted.
  • Participants included overweight, dyslipidaemic men and treated-hypertensive Type 2 diabetic patients.
  • Participants were randomized to receive 4 g daily of EPA or DHA, or an olive oil placebo.

Main Results:

  • Both EPA and DHA supplementation significantly reduced plasma F(2)-isoprostanes compared to placebo.
  • EPA reduced F(2)-isoprostanes by 24% (Study A) and 19% (Study B).
  • DHA reduced F(2)-isoprostanes by 14% (Study A) and 23% (Study B).
  • Reductions were independent of changes in plasma arachidonic acid.
  • No F(3)- or F(4)-isoprostanes were detected in plasma.

Conclusions:

  • EPA and DHA supplementation effectively reduce in vivo oxidant stress in humans.
  • Plasma F(2)-isoprostanes serve as a reliable marker for omega-3s' antioxidant effects.
  • Findings support the role of omega-3 fatty acids in mitigating oxidative stress.