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Related Concept Videos

Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

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Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
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Published on: September 20, 2024

Perinatal outcomes in post-thyroidectomy pregnancies.

Neta Cohen1, Amalia Levy, Arnon Wiznitzer

  • 1Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er Sheva, Israel.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
|June 15, 2010
PubMed
Summary
This summary is machine-generated.

Pregnancy after total thyroidectomy increases risks for adverse obstetric outcomes like placental abruption and C-section delivery. This risk is higher compared to hypothyroidism from other causes.

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Published on: May 12, 2023

Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Reproductive Medicine

Background:

  • Thyroidectomy is a common surgical procedure.
  • Hypothyroidism can affect pregnancy outcomes.
  • The specific impact of total thyroidectomy on pregnancy warrants investigation.

Purpose of the Study:

  • To investigate pregnancy outcomes in women following total thyroidectomy.
  • To compare these outcomes with pregnancies in women with hypothyroidism from other causes and those without hypothyroidism.

Main Methods:

  • Retrospective study design.
  • Comparison of three groups: post-total thyroidectomy (n=50), hypothyroidism (n=1015), and no hypothyroidism (n=200,000).
  • Analysis of adverse obstetric and perinatal outcomes.

Main Results:

  • Total thyroidectomy group showed significantly higher rates of placental abruption (6.1%) and caesarean delivery (33.3%) compared to other groups.
  • Total thyroidectomy was independently associated with placental abruption and fertility treatment.
  • No significant differences in perinatal outcomes (Apgar scores, perinatal mortality) were observed between groups.

Conclusions:

  • Women post-total thyroidectomy face increased risks for adverse obstetric outcomes.
  • The risk of adverse outcomes is higher in post-total thyroidectomy pregnancies than in those with hypothyroidism from other causes.
  • Monitoring and management strategies may be needed for pregnant women post-thyroidectomy.