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Structural and functional MRI in children with renal disease: first experience
Bettina Jørgensen1, Kristian Karstoft, Troels Munch Jørgensen
1Institute of Clinical Medicine, Aarhus University Hospital, Denmark.
Zeitschrift Fur Medizinische Physik
|June 15, 2010
Summary
This study explored MRI for evaluating kidney structure and function in children with renal dysfunction. While MRI provided detailed anatomical insights, it underestimated glomerular filtration rate (GFR) compared to radionuclide methods.
Area of Science:
- Pediatric Nephrology
- Medical Imaging
- Renal Function Assessment
Background:
- Children with renal dysfunction require accurate structural and functional assessment.
- Radionuclide methods are standard for measuring glomerular filtration rate (GFR).
- Magnetic Resonance Imaging (MRI) offers potential for comprehensive kidney evaluation.
Purpose of the Study:
- To assess the feasibility of using MRI for structural and functional evaluation in children with renal dysfunction.
- To compare quantitative MRI measurements of renal function with established radionuclide techniques.
- To explore MRI's utility for estimating renal cortical volume and single kidney function.
Main Methods:
- Eight children with renal impairment underwent MRI after radioisotopic GFR measurements.
- MRI protocol included anatomical/structural and dynamic contrast-enhanced sequences.
- Graphical Patlak approach was used to estimate GFR from dynamic MRI data.
Main Results:
- MRI successfully characterized intrarenal anatomy (cortex, medulla, pelvicalyceal arrangement) in all participants.
- Dynamic contrast-enhanced MRI generally underestimated GFR compared to Cr-EDTA measurements (range: -2% to -43%).
Conclusions:
- MRI can serve as a single-modality approach for evaluating pediatric renal structure and function.
- A clinical strategy for estimating renal cortical volume and single kidney function using MRI was presented.
- The use of MRI contrast agents in renal patients warrants caution due to Nephrogenic Systemic Fibrosis (NSF) risk.
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