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Updated: Jun 12, 2026
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Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
Published on: November 10, 2023
Effects of the bone marrow microenvironment on hematopoietic malignancy
Maria Askmyr1, Julie Quach, Louise E Purton
1St. Vincent's Institute, Fitzroy, Victoria, 3065, Australia.
Bone
|June 15, 2010
Summary
The bone marrow microenvironment, once thought passive, actively regulates blood cell development (hematopoiesis). Emerging evidence suggests these microenvironment cells also contribute to the development of blood cancers.
Area of Science:
- Hematology
- Cell Biology
- Oncology
Background:
- The bone marrow (BM) is crucial for hematopoiesis, the continuous development of blood cells.
- The BM microenvironment comprises non-hematopoietic cells supporting hematopoietic stem and progenitor cells.
- Recent studies highlight the active regulatory roles of BM microenvironment cells in hematopoiesis.
Purpose of the Study:
- To review the role of bone marrow microenvironment cells in regulating hematopoiesis.
- To explore data linking BM microenvironment cells to hematopoietic diseases.
- To summarize evidence for the microenvironment's role in hematopoietic malignancy.
Main Methods:
- Literature review of studies on bone marrow microenvironment and hematopoiesis.
- Analysis of data implicating microenvironment cells in hematopoietic diseases.
- Synthesis of findings on microenvironment's role in cancer initiation and progression.
Main Results:
- Bone marrow microenvironment cells actively regulate hematopoiesis.
- These cells are increasingly recognized for their contribution to hematopoietic diseases.
- Evidence indicates microenvironment cells play a role in initiating and progressing blood cancers.
Conclusions:
- The bone marrow microenvironment is not merely a supportive niche but an active participant in blood cell regulation.
- Dysregulation within the BM microenvironment can drive the development of hematopoietic malignancies.
- Targeting the BM microenvironment may offer new therapeutic strategies for blood cancers.
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