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Small cytokine superfamily.

B Sherry¹, A Cerami

¹Laboratory of Medical Biochemistry, Rockefeller University, New York, New York 10021-6399.

Current Opinion in Immunology

|February 1, 1991

Summary

A new family of small inducible cytokines (scy) shows similarities in function and structure. However, distinct activities of these cytokines offer precise control over immune and inflammatory responses.

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Area of Science:

Immunology
Molecular Biology
Genomics

Background:

A novel superfamily of small inducible cytokines, designated 'scy', has been identified.
These cytokines share significant similarities in activity, regulation, and genomic structure.

Purpose of the Study:

To explore the specific biological activities and contexts where scy cytokines differ.
To understand how these differences enable fine-tuning of immune and inflammatory responses.

Main Methods:

Comparative analysis of scy cytokine activities.
Investigation of regulatory mechanisms.
Examination of genomic structures.

Main Results:

Identified specific biological contexts highlighting differences among scy cytokines.
Demonstrated potential for precise modulation of immune responses through scy cytokine variations.

Conclusions:

Scy cytokines, despite structural similarities, exhibit distinct functional properties.
These distinct properties provide mechanisms for fine-tuning immune and inflammatory processes.

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