Related Experiment Video

Updated: Jun 12, 2026

Surgical Management of Meatal Stenosis with Meatoplasty
04:53

Surgical Management of Meatal Stenosis with Meatoplasty

Published on: November 30, 2010

Investigation and initial management of ambiguous genitalia

S Faisal Ahmed1, Martina Rodie

  • 1Department of Child Health, Royal Hospital For Sick Children, University of Glasgow, Yorkhill, Glasgow G3 8SJ, United Kingdom. s.f.ahmed@clinmed.gla.ac.uk

Best Practice & Research. Clinical Endocrinology & Metabolism
|June 15, 2010
PubMed

Insights

Infants rarely have ambiguous genitalia; expert multidisciplinary evaluation is crucial for disorders of sex development (DSD). Paediatric endocrinologists lead systematic clinical assessment, requiring deep knowledge of pathophysiology and diagnostic tools.

Area of Science:

  • Endocrinology
  • Genetics
  • Paediatrics

Background:

  • Ambiguous genitalia in infants is rare, necessitating specialized care.
  • Disorders of Sex Development (DSD) require a coordinated, expert approach.
  • Multidisciplinary teams are essential for managing complex DSD cases.

Purpose of the Study:

  • To emphasize the importance of expert evaluation for infants with ambiguous genitalia.
  • To highlight the central role of paediatric endocrinologists in DSD management.
  • To underscore the need for comprehensive knowledge in diagnosing DSD.

Main Methods:

  • Systematic clinical evaluation of infants with suspected DSD.
  • Utilizing a multidisciplinary team approach for diagnosis and management.
  • Leveraging knowledge of underlying pathophysiology and diagnostic tools.

Main Results:

  • Expert-led, multidisciplinary teams are vital for evaluating and managing DSD.
  • Paediatric endocrinologists play a key role in leading clinical assessments.
  • Thorough understanding of pathophysiology and investigative tools is critical for accurate diagnosis.

Conclusions:

  • Infants with ambiguous genitalia require expert, multidisciplinary care.
  • Paediatric endocrinologists are central to the systematic evaluation of DSD.
  • Accurate diagnosis hinges on deep knowledge of disease mechanisms and available tests.

More Related Videos

Clinical Application of 24 G Cannula Needle and 3-0 Polypropylene Suture in Vas Deferens Exploration07:21

Clinical Application of 24 G Cannula Needle and 3-0 Polypropylene Suture in Vas Deferens Exploration

Published on: February 10, 2023

Related Concept Videos

Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Urologic Endoscopic Procedure: Cystoscopic Examination01:28

Urologic Endoscopic Procedure: Cystoscopic Examination

Meaning of Cystoscopic Examination:Cystoscopy is an essential diagnostic tool in urology that is used to assess the structure and function of the genitourinary system. It provides a direct view of the urethra, bladder, and, in some cases, the ureteral openings. This procedure helps detect structural abnormalities, infections, cancers, and blockages in the urinary tract. There are two types of cystoscopy:Flexible cystoscopy is commonly performed in outpatient settings due to its less invasive...
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Nursing Assessment of the Genitourinary System II: Inspection and Palpation01:26

Nursing Assessment of the Genitourinary System II: Inspection and Palpation

The nursing assessment of the genitourinary (GU) system involves a systematic inspection and palpation to identify abnormalities in the kidneys, bladder, and surrounding structures.InspectionMouth: Inspect for signs of kidney dysfunction, such as stomatitis (inflammation of the mouth) and ammonia breath, which may occur in advanced kidney disease due to the buildup of urea, breaking down into ammonia.Skin: Check for pallor, which could indicate anemia caused by kidney disease. Look for...
Imaging Studies VI: Voiding Cystourethrography and Cystography01:22

Imaging Studies VI: Voiding Cystourethrography and Cystography

Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...