Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leprosy and cell-mediated immunity.

G Kaplan1, Z A Cohn

  • 1Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York 10021.

Current Opinion in Immunology
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum YKL-40 level is correlated with apnea hypopnea index in patients with obstructive sleep apnea sindrome.

European review for medical and pharmacological sciences·2017
Same author

Retraction notice to: PS124-Efficacy and Safety of Induction Dosing of Vedolizumab for Reducing Biliary Inflammation in Primary Sclerosing Cholangitis (PSC) in Individuals with Inflammatory Bowel Disease [J Hepatol 64 (2016) S199].

Journal of hepatology·2017
Same author

RETRACTED: Efficacy and Safety of Induction Dosing of Vedolizumab for Reducing Biliary Inflammation in Primary Sclerosing Cholangitis (Psc) in Individuals with Inflammatory Bowel Disease.

Journal of hepatology·2016
Same author

The use of short message services (SMS) to provide medical updating to parents in the NICU.

Journal of perinatology : official journal of the California Perinatal Association·2016
Same author

The joint association of self-rated health and diabetes status on 14-year mortality in elderly men and women.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2016
Same author

Socio-economic patterning in adulthood and depressive symptoms among a community sample of older adults in the United States.

Public health·2015
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Intradermal purified protein derivative (PPD) and recombinant human interleukin-2 (IL-2) induce local immune responses in leprosy patients. Interleukin-2 also promotes a systemic response and reduces Mycobacterium leprae burden.

Area of Science:

  • Immunology
  • Microbiology
  • Dermatology

Background:

  • Leprosy, caused by Mycobacterium leprae, is a chronic infectious disease.
  • Cell-mediated immunity plays a crucial role in controlling M. leprae infection.
  • The lepromatous form of leprosy is characterized by a deficient cell-mediated immune response.

Purpose of the Study:

  • To investigate the immunomodulatory effects of purified protein derivative of tuberculin (PPD) and recombinant human interleukin-2 (IL-2) in lepromatous leprosy patients.
  • To assess the impact of these agents on local and systemic cell-mediated immunity.
  • To evaluate their efficacy in reducing the bacillary load of Mycobacterium leprae.

Main Methods:

  • Intradermal injection of PPD in lepromatous leprosy patients.

Related Experiment Videos

  • Intradermal injection of recombinant human IL-2 in lepromatous leprosy patients.
  • Monitoring local cell-mediated immune responses and bacillary destruction.
  • Administering IL-2 over an 8-day period to evaluate systemic effects.

    • Main Results:

    • Intradermal PPD induced a local cell-mediated immune response and destruction of Mycobacterium leprae.
    • Intradermal IL-2 also elicited a local cell-mediated immune response.
    • An 8-day administration of IL-2 resulted in a systemic cell-mediated immune response and a reduction in bacillary burden.

    Conclusions:

    • Both PPD and IL-2 can stimulate local immune responses in lepromatous leprosy.
    • Recombinant human IL-2 demonstrates potential as a therapeutic agent by inducing both local and systemic cell-mediated immunity.
    • IL-2 treatment may lead to a significant reduction in Mycobacterium leprae burden, offering a promising avenue for leprosy treatment.