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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Severe infections in a cohort of patients with systemic lupus erythematosus]
Rocío González León1, María Jesús Castillo Palma, Francisco José García Hernández
1Unidad de Colagenosis e Hipertensión Pulmonar, Servicio de Medicina Interna, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain.
Background And Objective:
To study severe infectious complications in a cohort of patients with systemic lupus erythematosus (SLE).
Patients And Method:
Retrospective study of 705 patients followed from January 1980 to January 2008. Data are expressed in percentages.
Results:
The frequency of severe infectious was 38.6%. The etiology was bacterial 54.4%, viric 30.4% and opportunist in 15.2% patients. Involved organs were: Lung 38.2%, kidney 48.9%, central nervous system 43%. 43.75% patients received pulsed ciclofosfamide therapy and 88.6% received glucocorticoids (39.7% pulsed). The mortality was 27.7%.
Conclusions:
At present, infection is an important cause of mortality in patients with SLE. Early diagnosis of infectious complications is very important in SLE.
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