Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Molecular Weight of Step-Growth Polymers01:08

Molecular Weight of Step-Growth Polymers

Step growth polymerization involves bi or multifunctional monomers. Bifunctional monomers react to form linear step growth polymers, whereas multifunctional monomers react to form non-linear or branched polymers.
As the step-growth polymerization involves step-wise condensation of monomers, the molecular weight also builds up eventually. Consequently, high molecular weight polymers are obtained at the late stages of the polymerization, where 99% of monomers have been consumed.
The extent of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D Printing and Electrospinning of PLLA-<i>co</i>-CL/PDLA Blends as Potential Materials for Cardiovascular Implants.

ACS biomaterials science & engineering·2026
Same author

Physicochemical and Biological Characterization of the TLR7 Agonist SZU-106.

Pharmaceutical research·2026
Same author

Tyrosinase Cross-Linked PEG Hydrogels with DAT and DATT as Artificial Substrates: Design, Structure, and Functions.

Biomacromolecules·2026
Same author

Gelatin-based porous scaffolds: design concepts, production, and applications in precision regenerative medicine.

Materials today. Bio·2026
Same author

A water-recyclable, robust, and self-healing sugar-based supramolecular network enabled by Maillard-analogous initialization of polymerization.

Materials horizons·2025
Same author

Alternative Techniques for Porous Microparticle Production: Electrospraying, Microfluidics, and Supercritical CO<sub>2</sub>.

Pharmaceutical research·2025

Related Experiment Video

Updated: Jun 12, 2026

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

Comparing techniques for drug loading of shape-memory polymer networks--effect on their functionalities.

Christian Wischke1, Axel T Neffe, Susi Steuer

  • 1Center for Biomaterial Development, Institute of Polymer Research, GKSS Research Center Geesthacht GmbH, Kantstrasse 55, 14513 Teltow, Germany.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|June 15, 2010
PubMed
Summary

Researchers developed oligo[(epsilon-caprolactone)-co-glycolide]dimethacrylate (oCG-DMA) networks for drug delivery. Loading drugs before crosslinking offers controlled release, while swelling provides high initial doses, impacting drug delivery systems.

More Related Videos

Shape Memory Polymers for Active Cell Culture
10:53

Shape Memory Polymers for Active Cell Culture

Published on: July 4, 2011

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Related Experiment Videos

Last Updated: Jun 12, 2026

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

Shape Memory Polymers for Active Cell Culture
10:53

Shape Memory Polymers for Active Cell Culture

Published on: July 4, 2011

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Oligo[(epsilon-caprolactone)-co-glycolide]dimethacrylate (oCG-DMA) networks offer tunable properties like hydrophilicity and network density.
  • These networks exhibit shape-memory functionality and controlled degradation, making them promising for biomedical applications.
  • Drug loading strategies can significantly influence the release profile and material performance.

Purpose of the Study:

  • To synthesize and characterize oCG-DMA networks with varying glycolide content and molecular weights.
  • To investigate the effects of two drug loading methods (pre-crosslinking and post-swelling) on drug payload and release kinetics.
  • To evaluate the impact of drug loading on the shape-memory and degradation properties of the oCG-DMA networks.

Main Methods:

  • Synthesis of oCG-DMA networks via crosslinking with varying precursor molecular weights and glycolide content.
  • Loading of ethacridine lactate (hydrophilic model drug) either before or after network formation.
  • Characterization of network properties (hydrophilicity, density, morphology) and drug release profiles.
  • Assessment of shape-memory functionality and degradation behavior of loaded and unloaded networks.

Main Results:

  • oCG-DMA networks with diverse properties were successfully synthesized.
  • Drug loading, particularly by swelling, resulted in low payloads with burst release, though slightly higher for more hydrophilic networks.
  • Loading before crosslinking yielded minimal burst release and sustained drug delivery over extended periods.
  • Drug loading caused only minor alterations in shape-memory and degradation characteristics for most materials.

Conclusions:

  • oCG-DMA networks provide a versatile platform for drug delivery with tunable properties.
  • The choice of drug loading method is critical: swelling for high initial doses, pre-crosslinking for sustained release and low burst.
  • These materials can be tailored for specific applications requiring controlled drug release, shape-memory effects, and predictable degradation.