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Updated: Jun 12, 2026

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
Published on: November 7, 2013
Hijacking cellular garbage cans
Sonja Welsch1, Jacomine Krijnse Locker
1European Molecular Biology Laboratory, Structural and Computational Biology Unit, 69117 Heidelberg, Germany.
Abstract:
Viruses are perfect opportunists that have evolved to modify numerous cellular processes in order to complete their replication cycle in the host cell. An article by Reggiori and coworkers in this issue of Cell Host & Microbe reveals how coronaviruses can divert a cellular quality control pathway that normally functions in degradation of mis-folded proteins to replicate the viral genome.
Insights
Coronaviruses hijack cellular protein quality control pathways for viral genome replication. This study reveals how these viruses exploit host cell machinery to ensure their own propagation.
Area of Science:
- Virology
- Cell Biology
- Molecular Biology
Background:
- Viruses are obligate intracellular parasites that manipulate host cell processes.
- Cellular quality control pathways are essential for maintaining protein homeostasis and degrading misfolded proteins.
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