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Underestimation of influenza viral infection in childhood asthma exacerbations

Alexis Mandelcwajg1, Florence Moulin, Cedric Menager

  • 1Pediatric Unit, Paris Descartes University, and AP-HP Saint Vincent de Paul-Cochin Hospital, Paris, France.

The Journal of Pediatrics
|June 15, 2010
PubMed

Insights

Bocavirus and respiratory syncytial virus are common in children with asthma exacerbations. Influenza A virus prevalence is significantly higher in ambulatory patients, suggesting an underestimated burden in asthma.

Area of Science:

  • Pediatric respiratory infections
  • Asthma exacerbations
  • Viral diagnostics

Background:

  • Asthma exacerbations in children are frequently associated with viral respiratory infections.
  • Previous studies have focused on common viruses, potentially overlooking others.
  • Understanding the viral etiology is crucial for effective management.

Purpose of the Study:

  • To investigate the prevalence of Bocavirus, respiratory syncytial virus, and influenza A virus in children experiencing asthma exacerbations.
  • To compare viral detection rates between hospitalized and ambulatory pediatric patients.

Main Methods:

  • Retrospective analysis of respiratory samples from children with asthma exacerbations.
  • Use of molecular diagnostic methods for viral detection.
  • Comparison of viral detection rates across different clinical settings.

Main Results:

  • Bocavirus was detected in 11.6% of hospitalized and 13% of ambulatory children.
  • Respiratory syncytial virus prevalence was 13.5% in hospitalized and 17.7% in ambulatory children.
  • Influenza A virus was found in 2.6% of hospitalized children but significantly higher in 14.1% of ambulatory patients (P<.001).

Conclusions:

  • The study highlights the significant role of Bocavirus and RSV in pediatric asthma exacerbations.
  • Influenza A virus burden in ambulatory asthma patients appears to be underestimated.
  • Comprehensive viral testing is recommended for children with asthma exacerbations.

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