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Updated: Jun 12, 2026

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
[T(H)17 lymphocytes: induction, phenotype, functions, and implications in human disease and therapy]
1Service de médecine interne et immunologie clinique, hôpital du Bocage, CHU de Dijon, Dijon cedex, France.
Summary
Naive CD4(+) T helper cells differentiate into specialized subsets, including T(H)17 cells. This review explores T(H)17 cell induction, function, and role in immunity and disease.
Area of Science:
- Immunology
- Cellular immunology
- Adaptive immunity
Context:
- CD4(+) T helper cells are crucial for adaptive immunity, differentiating into subsets with distinct effector functions.
- T(H)1 cells drive cellular immunity, T(H)2 cells drive humoral immunity, and regulatory T cells (Treg) suppress immune responses.
- T(H)17 cells, a recently identified subset, produce IL-17 and are vital for anti-infectious and inflammatory responses.
Purpose:
- To review current knowledge on T(H)17 cells.
- To detail T(H)17 cell induction, phenotype, and functions.
- To discuss the implications of T(H)17 cells in host defense, human diseases, and therapeutic potential.
Summary:
- T(H)17 cells are characterized by IL-17 production and play a significant role in anti-infectious and inflammatory immune responses.
- This review consolidates information on T(H)17 cell differentiation, characteristics, and involvement in various biological processes.
- Understanding T(H)17 cells is key to exploring their therapeutic applications in immune-related conditions.
Impact:
- Provides a comprehensive overview of T(H)17 cell biology for researchers and clinicians.
- Highlights the dual role of T(H)17 cells in host defense and inflammatory diseases.
- Identifies T(H)17 cells as potential targets for novel immunotherapies.
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