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Glyoxalase-I mRNA expression and CCK-4 induced panic attacks
Daniela Eser1, Manfred Uhr, Gregor Leicht
1Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Nussbaumstrasse 7, 80336 Munich, Germany. daniela.eser@med.uni-muenchen.de
Journal of Psychiatric Research
|June 15, 2010
Summary
This study found no link between glyoxalase-1 (GLO1) mRNA levels and acute panic anxiety in healthy individuals. Further research is needed to understand GLO1's role in anxiety disorders.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- The enzyme glyoxalase-1 (GLO1) is implicated in anxiety-related behaviors, but animal studies show conflicting results.
- No prior research has examined GLO1 mRNA expression in relation to human anxiety.
Purpose of the Study:
- To investigate the relationship between GLO1 mRNA expression in peripheral blood cells and cholecystokinin-tetrapeptide (CCK-4) induced panic anxiety in healthy subjects.
Main Methods:
- Twenty-three healthy volunteers received CCK-4 challenge.
- GLO1 mRNA expression was measured using quantitative real-time polymerase chain reaction.
- Baseline anxiety and panic response were assessed using the State-Trait-Anxiety-Inventory (STAI) and Panic Symptom Scale (PSS).
Main Results:
- CCK-4 induced significant anxiety and increased heart rate.
- GLO1 mRNA expression did not correlate with baseline anxiety (state or trait).
- No correlation was found between GLO1 mRNA levels and the severity of CCK-4 induced anxiety.
Conclusions:
- GLO1 mRNA expression is not associated with the acute panic response to CCK-4 in healthy individuals.
- Further studies are required to clarify GLO1's role in anxiety disorders and resolve discrepancies with preclinical findings.
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