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Updated: Jun 12, 2026
06:39
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
Constitutional inv(3) in myelodysplastic syndromes
Caroline Gahrton1, Hareth Nahi, Monika Jansson
1Department of Medicine, Karolinska Institutet Huddinge, Stockholm, Sweden.
Leukemia Research
|June 15, 2010
Summary
The pericentric inversion on chromosome 3, inv(3), is uncommon. This study suggests inv(3) may be a risk factor for developing myelodysplastic syndromes, a type of hematologic malignancy.
Area of Science:
- Cytogenetics
- Hematology
- Oncology
Background:
- The constitutional pericentric inversion on chromosome 3, denoted as inv(3), is infrequently observed in the general population.
- Understanding chromosomal abnormalities is crucial for diagnosing and managing hematologic disorders.
Purpose of the Study:
- To investigate the potential association between inv(3) and the development of hematologic malignancy.
- To determine if inv(3) is more prevalent in patients with myelodysplastic syndromes (MDS).
Main Methods:
- Chromosomal analysis using the Q-banding technique was performed on bone marrow cells.
- A total of 890 patients diagnosed with various hematologic disorders were included in the study.
- The frequency of inv(3) was compared between patients with MDS and other hematologic conditions.
Main Results:
- Inv(3) was detected in 3.8% (34 out of 890) of patients with hematologic disorders.
- The frequency of inv(3) was significantly higher in patients with myelodysplastic syndromes (6.2%) compared to other hematologic disorders (2.9%) (p=0.02).
Conclusions:
- The increased prevalence of inv(3) in patients with MDS suggests a potential role in disease development.
- Inv(3) may represent a risk factor for the pathogenesis of myelodysplastic syndromes.
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