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Updated: Jun 12, 2026
08:29
Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
Published on: October 2, 2014
At a crossroads in oncology.
1Amgen, Inc., 1120 Veterans Blvd, South San Francisco, CA 94080, USA. akamb@amgen.com
Current Opinion in Pharmacology
|June 15, 2010
Summary
Current cancer therapies face significant hurdles due to cancer's genetic complexity. New therapeutic strategies are needed to overcome these challenges in clinical oncology.
Area of Science:
- Oncology
- Cancer Biology
- Therapeutics Development
Background:
- The current paradigm of cancer therapy faces limitations.
- Progress in clinical oncology has been hampered by key obstacles.
- Understanding cancer's genetic complexity is crucial.
Purpose of the Study:
- To survey the current state of cancer therapy and clinical oncology.
- To identify and address clinical and biological obstacles in cancer treatment.
- To advocate for novel approaches in cancer therapy.
Main Methods:
- Review of current cancer therapy paradigms.
- Analysis of clinical and biological impediments.
- Examination of genetic complexity and targeted therapy performance.
Main Results:
- Cancer exhibits significant genetic complexity.
- Targeted therapies show mixed clinical performance.
- Industry pipelines for cancer drugs are largely homogeneous.
Conclusions:
- Existing approaches to cancer therapy require re-evaluation.
- New therapeutic strategies are essential for advancing cancer treatment.
- Addressing the identified obstacles is critical for future progress.
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