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Pairwise Growth Competition Assay for Determining the Replication Fitness of Human Immunodeficiency Viruses
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Published on: May 4, 2015

Postmortem viability of the human immunodeficiency virus

K Püschel1, F Mohsenian, R Laufs

  • 1Institute of Forensic Medicine, University of Hamburg, Federal Republic of Germany.

International Journal of Legal Medicine
|March 1, 1991
PubMed

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As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...