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The NIHSS-plus: improving cognitive assessment with the NIHSS.

Rebecca F Gottesman1, Jonathan T Kleinman, Cameron Davis

  • 1Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA. rgottesm@jhmi.edu

Behavioural Neurology
|June 15, 2010
PubMed
Summary
This summary is machine-generated.

The National Institutes of Health Stroke Scale (NIHSS) may underestimate stroke severity. Adding simple cognitive tests like line cancellation and visual perception to the NIHSS improves stroke volume prediction.

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Area of Science:

  • Neurology
  • Neuroimaging
  • Cognitive Science

Background:

  • The National Institutes of Health Stroke Scale (NIHSS) has limitations in assessing cognitive dysfunction and dominant hemisphere strokes.
  • Patients with significant strokes may receive low NIHSS scores due to these limitations.
  • Integrating simple cognitive assessments could enhance the clinical and research utility of the NIHSS.

Purpose of the Study:

  • To evaluate the predictive value of adding cognitive tests to the NIHSS for stroke volume.
  • To determine if cognitive assessments improve the accuracy of stroke severity estimation.

Main Methods:

  • Studied 200 patients with acute non-dominant hemispheric stroke.
  • Assessed cognitive function and performed MRI with diffusion-weighted imaging (DWI) within 5 days.
  • Used linear regression to analyze the predictive role of NIHSS and cognitive tests on DWI volumes.

Main Results:

  • NIHSS alone predicted DWI volume.
  • Line cancellation and visual perception tasks also predicted DWI volume.
  • In a multivariate model, NIHSS, line cancellation errors, and visual perception significantly improved the prediction of total infarct volume.

Conclusions:

  • Adding line cancellation and visual perception tasks to the NIHSS significantly enhances stroke volume prediction.
  • An "NIHSS-plus" incorporating these cognitive tests could offer a more accurate representation of ischemic tissue volume.
  • Further prospective validation of this enhanced scale is recommended.