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Updated: Jun 12, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

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Published on: June 7, 2019

SWItching on the transcriptional circuitry in melanoma

Srinivas Vinod Saladi1, Himangi Marathe, Ivana L de la Serna

  • 1Department of Biochemistry and Cancer Biology, University of Toledo College of Medicine, Toledo, OH, USA.

Epigenetics
|June 15, 2010
PubMed

Insights

This review highlights SWI/SNF chromatin remodeling enzymes as key epigenetic regulators in melanoma. These enzymes influence transcriptional circuits affected by genetic alterations, impacting melanoma progression and resistance to therapy.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Melanoma is an aggressive, lethal skin cancer resistant to current therapies.
  • Melanoma development involves genetic alterations affecting gene expression and transcriptional circuitry.
  • Tumorigenesis is driven by genetic alterations and epigenetic changes.

Purpose of the Study:

  • To review recent studies on epigenetic regulators in melanoma.
  • To discuss the role of SWI/SNF chromatin remodeling enzymes in melanoma.

Main Methods:

  • Literature review of recent studies.
  • Analysis of epigenetic regulation in melanoma.

Main Results:

  • SWI/SNF enzymes are implicated as epigenetic regulators.
  • These enzymes affect transcriptional circuits in melanoma.
  • Their role is linked to genetic alterations common in melanoma.

Conclusions:

  • SWI/SNF chromatin remodeling enzymes are crucial epigenetic regulators in melanoma.
  • Understanding their function offers insights into melanoma progression.
  • Targeting these enzymes may overcome therapeutic resistance.

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