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Updated: Jun 12, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Th17 cells and HIV infection.

Aimee Elhed¹, Derya Unutmaz

¹Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA.

Current Opinion in HIV and AIDS

|June 15, 2010

Summary

Reduced T helper 17 (Th17) cells are observed in HIV and SIV infections, impacting mucosal defenses and potentially leading to chronic immune activation and opportunistic infections.

Area of Science:

Immunology
Virology
Pathogenesis

Background:

T helper 17 (Th17) cells are crucial for host defense against pathogens and implicated in autoimmune diseases.
Perturbation of Th17 cells has been noted in HIV infection and simian immunodeficiency virus (SIV) infection.
Th17 cells play a role in maintaining mucosal immunity and preventing chronic immune activation.

Purpose of the Study:

To review recent literature on the perturbation and role of Th17 cells in HIV pathogenesis.
To discuss Th17 cell deficiency in HIV/SIV infection and its impact on mucosal defenses.
To explore the contribution of Th17 cell deficiency to chronic immune activation.

Main Methods:

Literature review of recent studies on Th17 cells in HIV and SIV infection.

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Analysis of findings regarding Th17 cell infection, depletion, and correlation with disease progression.

Comparison of Th17 cell status in pathogenic vs. non-pathogenic SIV infections in nonhuman primates.

Main Results:

Th17 cells are infected in vitro by HIV and SIV.
Significant depletion of Th17 cells occurs in the gastrointestinal tract of HIV-infected individuals.
Th17 cell depletion in nonhuman primates correlates with pathogenic SIV infection and AIDS progression, while remaining intact in non-pathogenic SIV infection.

Conclusions:

Th17 cell perturbation is a significant finding in HIV and SIV infections.
Disruption of mucosal defenses, particularly in the gastrointestinal tract, is linked to Th17 cell deficiency.
Understanding Th17 cell dynamics may aid in predicting opportunistic infections in HIV disease.