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Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

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Tests for ovarian reserve: reliability and utility.

Thaís S Domingues¹, André M Rocha, Paulo C Serafini

¹Huntington Medicina Reprodutiva, Av. República do Líbano, 529 - São Paulo, São Paulo 04501-000, Brazil.

Current Opinion in Obstetrics & Gynecology

|June 15, 2010

Summary

Ovarian reserve tests like AMH and AFCs predict response to ovulation induction but cannot reliably predict pregnancy or menopause onset. Use with caution for reproductive counseling.

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Area of Science:

Reproductive Endocrinology
Gynecologic Oncology
Assisted Reproductive Technologies

Background:

Ovarian reserve testing is crucial for fertility assessment.
Current tests include hormonal and ultrasonographic markers.
These tests have limitations in accuracy, invasiveness, and utility.

Purpose of the Study:

To review ovarian reserve tests for ovulation induction and fertility capacity.
To assess their application in predicting natural ovarian failure.
To evaluate their use in estimating ovarian function post-cancer treatment.

Main Methods:

Review of hormonal markers: FSH, estradiol, inhibin-B, AMH.
Review of ultrasonographic markers: ovarian volume, AFCs.
Correlation studies between AFCs and AMH for predicting response to ovulation induction.

Main Results:

Serum AMH levels and AFCs reliably predict ovarian response to ovulation induction.
No current ovarian reserve test reliably predicts pregnancy after assisted conception.
Ovarian reserve tests cannot predict menopause onset or assess ovarian sufficiency post-cancer treatment.

Conclusions:

AMH and AFCs are valuable for predicting ovulation induction response.
Caution is advised when using ovarian reserve tests for reproductive life-programming counseling.
Current evidence does not support using these tests for post-cancer treatment ovarian sufficiency assessment.