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Effect of Bifidobacterium animalis subsp lactis supplementation in preterm infants: a systematic review of randomized

Hania Szajewska1, Stefano Guandalini, Lorenzo Morelli

  • 1Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland. hania@ipgate.pl

Journal of Pediatric Gastroenterology and Nutrition
|June 15, 2010
PubMed

Insights

Bifidobacterium animalis subsp lactis CNCM I-3446 supplementation shows potential benefits for preterm infants, improving gut health markers. Further research is needed to confirm clinical outcomes and safety.

Area of Science:

  • Neonatal Medicine
  • Microbiology
  • Gastroenterology

Background:

  • Preterm infants are vulnerable to gut dysbiosis and associated complications.
  • Probiotic supplementation is being explored to modulate the gut microbiome in this population.

Purpose of the Study:

  • To systematically review the efficacy and safety of Bifidobacterium animalis subsp lactis CNCM I-3446 in preterm infants.
  • To update existing evidence on its impact on gut health and clinical outcomes.

Main Methods:

  • A systematic search of Cochrane Library, MEDLINE, and conference proceedings for randomized controlled trials (RCTs).
  • Inclusion criteria: RCTs in preterm infants (<37 weeks gestation and/or <2500g birth weight).
  • Contacted manufacturer for unpublished data.

Main Results:

  • Four RCTs (324 infants) were included.
  • B lactis increased fecal bifidobacteria, reduced Enterobacteriaceae and Clostridium spp., lowered stool pH and fecal calprotectin.
  • Increased fecal IgA and SCFAs, decreased intestinal permeability; no significant effect on necrotizing enterocolitis, sepsis, or antibiotic use.
  • Some effects on anthropometric parameters noted; no adverse events reported.

Conclusions:

  • B lactis supplementation shows encouraging evidence for beneficial effects in preterm infants.
  • Further studies are necessary to confirm clinically relevant outcomes and long-term safety.
Abstract

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