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Preneoplastic changes persist after IGF-IR downregulation and tumor regression

R A Jones1, J J Petrik, R A Moorehead

  • 1Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.

Oncogene
|June 15, 2010
PubMed
Summary

Targeting the type I insulin-like growth factor receptor (IGF-IR) can regress mammary tumors. However, IGF-IR targeting agents do not eradicate all tumor cells, allowing for rapid tumor re-emergence.

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