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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
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Basophil Activation Test for Allergy Diagnosis
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Published on: May 31, 2021

Immunotherapy in food allergy.

Toral Kamdar1, Paul J Bryce

  • 1Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, 240 E Huron, M315 Chicago, IL 60610, USA.

Immunotherapy
|June 15, 2010
PubMed
Summary

Food allergies stem from immune reactions to food proteins. Immunotherapy offers a promising approach to desensitize patients, potentially leading to tolerance and reducing severe reactions from accidental food ingestion.

Keywords:
food allergyfood hypersensitivityimmunotherapyoral immunotherapysublingual immunotherapy

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Area of Science:

  • Immunology
  • Allergy Research
  • Gastroenterology

Background:

  • Food allergies involve immune responses to food proteins, disrupting oral tolerance.
  • Reactions range from mild symptoms to life-threatening anaphylaxis.
  • Current management relies on strict food avoidance, posing compliance challenges.

Purpose of the Study:

  • To review the mechanisms underlying food allergies.
  • To provide an overview of current immunotherapeutic options for food allergies.
  • To explore future directions in novel therapeutic modalities for food allergy.

Main Methods:

  • Literature review of immunological mechanisms in food allergy.
  • Analysis of existing clinical evidence for various immunotherapy approaches.
  • Discussion of emerging therapeutic strategies.

Main Results:

  • Immunotherapy can induce desensitization, potentially leading to oral tolerance.
  • This approach may reduce the risk of severe reactions upon accidental ingestion.
  • Immunotherapy holds potential for overall health benefits in food-allergic individuals.

Conclusions:

  • Understanding food allergy mechanisms is crucial for developing effective treatments.
  • Immunotherapy represents a significant advancement beyond simple food avoidance.
  • Future research is focused on novel therapies to achieve sustained tolerance.