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Predicting pregnancy in HIV-1-discordant couples
Brandon L Guthrie1, Robert Y Choi, Rose Bosire
1Department of Epidemiology, University of Washington, Seattle, WA 98104-2499, USA. brguth@u.washington.edu
Pregnancy rates were high in HIV-1 discordant couples in Kenya. Desire for children may increase unprotected sex, necessitating safer conception strategies for these couples.
Area of Science:
- Global Health
- Infectious Diseases
- Reproductive Health
Background:
- HIV-1 discordant couples face unique reproductive challenges.
- Understanding pregnancy incidence is crucial for preventing mother-to-child HIV transmission.
Purpose of the Study:
- To determine the incidence and predictors of pregnancy in HIV-1 discordant couples in Nairobi, Kenya.
- To inform strategies for safer conception in this population.
Main Methods:
- Prospective cohort study of 454 HIV-1 discordant couples in Nairobi.
- Follow-up of women for up to 2 years to record pregnancies.
- Statistical analysis to determine pregnancy incidence and associated factors.
Main Results:
- One-year cumulative pregnancy incidence was 9.7%.
- Pregnancy rates were similar between HIV-1-infected and uninfected women.
- Higher incidence (22.2%) observed in women under 30 desiring children.
Conclusions:
- Pregnancy rates are significant in HIV-1 discordant couples.
- Desire for children may outweigh HIV transmission concerns, leading to increased risk.
- Safer conception methods are urgently needed for HIV-1 discordant couples.
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