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Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

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Published on: June 22, 2015

3R tau expression modifies behavior in transgenic mice.

Natalia Shiryaev¹, Yan Jouroukhin, Illana Gozes

¹The Adams Super Center for Brain Studies, The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, The Elton Laboratory for Neuroendocrinology, and the Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Journal of Neuroscience Research

|June 15, 2010

Summary

This summary is machine-generated.

Mice overexpressing the shortest human tau isoform (0N3R) showed improved passive avoidance memory at 7 months. This enhanced behavior correlated with reduced tau phosphorylation in specific brain regions, suggesting a complex role for tau in cognitive function.

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Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Tauopathy involves hyperphosphorylated tau protein accumulation in the brain, leading to dementia.
Understanding tau's role in cognitive function requires studying its various isoforms and phosphorylation states.

Purpose of the Study:

To evaluate tau-related behavior in a mouse model overexpressing the shortest human tau isoform (0N3R).
To investigate the impact of tau overexpression on learning, memory, and locomotion at different ages.
To analyze tau expression and phosphorylation patterns in specific brain regions.

Main Methods:

Utilized tau-transgenic (tau-tg) and control littermate mice.
Assessed learning and memory using the Morris water maze and passive avoidance tests.
Evaluated locomotion and anxiety-like behavior with open field and elevated plus maze tests.
Analyzed tau expression and phosphorylation levels in the subcortical region and cerebral cortex.

Main Results:

Tau-tg mice learned the Morris water maze at 1 month but not at 7 months, similar to controls.
At 7 months, tau-tg mice showed enhanced passive avoidance memory retention compared to controls.
Increased locomotion was observed in 7-month-old tau-tg mice; elevated plus maze showed increased arm entrance in tau-tg mice at 7 months.
Tau-tg mice exhibited increased tau expression with reduced phosphorylation in the subcortical region, but increased expression and phosphorylation in the cerebral cortex.

Conclusions:

Overexpression of the 0N3R human tau isoform in mice leads to enhanced passive avoidance behavior at 7-8 months.
This behavioral enhancement is associated with relative tau hypophosphorylation in the subcortical brain region.
Findings suggest a complex, region-specific relationship between tau phosphorylation and cognitive function in tauopathy models.