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Updated: Jun 12, 2026

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies
Published on: January 31, 2013
Eccentric contractions induce rapid isometric torque drop in dystrophin-deficient dogs
Christopher J Tegeler1, Robert W Grange, Daniel J Bogan
1Wake Forest University Health Sciences, Institute for Regenerative Medicine, 391 Technology Way, Winston-Salem, North Carolina 27101, USA.
Abstract:
We tested the hypothesis that eccentric contractions (ECCs) rapidly induce greater-than-normal isometric torque drop in dystrophin-deficient golden retriever muscular dystrophy (GRMD) muscles. ECCs were imposed by forcibly stretching activated muscles. The results indicate that isometric torque drop was greater in GRMD versus controls (P < 0.0001). Our findings support the hypothesis that ECCs induce greater-than-normal isometric torque drop in GRMD muscles. The magnitude of ECC-induced isometric torque loss may be an ideal clinical endpoint in the GRMD model.
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