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Updated: Jun 12, 2026

Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies
06:56

Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies

Published on: March 2, 2018

[The role of released membrane microparticles in pathogenesis of systemic inflammatory response]

V V Moroz, A B Salmina, A A Fursov

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |June 15, 2010
    PubMed

    Insights

    Released membrane particles (RMP) carrying adhesion molecules increase after aortocoronary bypass grafting (ACBG). This suggests RMP play a role in the systemic inflammatory response (SIR) following major surgery.

    Area of Science:

    • Cardiovascular Surgery
    • Immunology
    • Cell Biology

    Context:

    • Aortocoronary bypass grafting (ACBG) is a major surgical procedure.
    • Systemic inflammatory response (SIR) is a common complication after ACBG.
    • The role of released membrane particles (RMP) in SIR is not fully understood.

    Purpose:

    • To evaluate the contribution of RMP to the development of SIR after ACBG.
    • To investigate the characteristics of RMP, including surface adhesion molecules.
    • To explore the relationship between RMP, lymphocyte blebbing, and cytokine levels.

    Summary:

    • RMP expressing CD62L, CD62P, and CD62E were found to increase post-ACBG.
    • Increased RMP levels correlated with enhanced lymphocyte plasma membrane blebbing and elevated cytokine levels.
    • The study concludes that RMP originate from cell blebbing and are markers of intercellular communication in SIR.

    Impact:

    • Identifies RMP as a potential biomarker for SIR after ACBG.
    • Suggests novel mechanisms for RMP involvement in the body's response to surgical injury.
    • Provides insights into cell-to-cell communication during systemic inflammation.

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