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Updated: Aug 11, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
Published on: August 3, 2018
[The action of tumor necrosis factor on the microvascular endothelium and its role in the morphological changes in
Abstract:
Tumor necrosis factor exerts the systemic influence on endothelial cells in vivo. Structural changes in endotheliocytes lead to specific damage in the organs. Interstitial and alveolar edema develops in lung. Kupffer cell activation, change of sinusoid endothelial cell porosity, lipid dystrophia of hepatocytes are revealed in liver, damage of glomerular and peritubular capillaries, dystrophic changes of tubular epithelial cells are found out in kidney. The data obtained indicate that endothelial cells in microvessels are one of major cellular targets for action of tumor necrosis factor.
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