Related Experiment Video
Updated: Jun 12, 2026
04:42
Bacterial Cellulose Spheres that Encapsulate Solid Materials
Published on: February 26, 2021
Oxycellulose as mucoadhesive polymer in buccal tablets
Jan Gajdziok1, Martina Bajerová, Zuzana Chalupová
1Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. gajdziokj@vfu.cz
Drug Development and Industrial Pharmacy
|June 16, 2010
Summary
Oxycellulose sodium (NaOC) tablets show promising mucoadhesive and drug release properties, especially when combined with other polymers like HPMC or CMC-Na, for extended drug delivery applications.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Biomaterials
Background:
- Oxycellulose (OC) is a biodegradable and bioabsorbable cellulose derivative with applications in hemostasis and tissue healing.
- Emerging research highlights OC's antimicrobial, immunomodulating, and mucoadhesive properties, positioning it for advanced therapeutic systems.
Purpose of the Study:
- To evaluate the mucoadhesive properties and prolonged drug release capabilities of oxycellulose sodium (NaOC) in directly compressed tablets.
- To assess NaOC's performance as a mucoadhesive polymer, alone and in combination with other polymers, for extended drug delivery.
Main Methods:
- Tablets containing cetylpyridinium chloride (CPC) and NaOC (alone or combined with other mucoadhesive polymers) were prepared via direct compression.
- Physicochemical properties (friability, thickness, hardness) and mucoadhesive characteristics (residence time, strength) were evaluated.
- In vitro dissolution profiles were analyzed to determine the release rate of CPC over 8 hours.
Main Results:
- Tablets formulated with NaOC and hydroxypropylmethylcellulose (Methocel K100LV) or carboxymethylcellulose sodium exhibited optimal quality parameters.
- These optimized formulations demonstrated excellent mucoadhesion (residence time > 256 min, strength > 3.45 mN/mm²) and controlled CPC release (>81% in 8 hours).
- Higher concentrations of NaOC alone resulted in shorter adhesion times and faster drug release due to its solubility.
Conclusions:
- NaOC possesses favorable compressing, mechanical, and mucoadhesive properties for tablet formulation.
- Combinations of NaOC with specific polymers like HPMC or CMC-Na enhance tablet quality and achieve prolonged drug release.
- NaOC's inherent solubility influences adhesion time and release rate, necessitating careful formulation design for extended drug delivery.
Related Concept Videos
01:26Oral Drug Delivery Systems: Continuous-Release Systems
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
01:27Drug Delivery Systems: Different Types
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
01:23Oral Drug Delivery Systems: Introduction
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
01:23Ophthalmic Drug Delivery Systems
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
01:18Drug Delivery: Enteral Route
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...
Drugs in...