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Formation of Dispersible Taohong Siwu Tablets

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Published on: February 3, 2023

Surrogate functionality of celluloses as tablet excipients.

Carmen Cristina Díaz Ramírez¹, Leopoldo Villafuerte Robles

¹Department of Pharmacy, National School of Biological Sciences, National Polytechnic Institute of Mexico, Santo Tomás, DF, México, Mexico.

Drug Development and Industrial Pharmacy

|June 16, 2010

Summary

Generic celluloses from India and the US are satisfactory tablet excipients, though innovator brands show superior compactibility and disintegration. These generic celluloses offer potential as filler, binder, and disintegrant in tablet formulations.

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Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Excipient selection necessitates evaluating functional characteristics due to diverse sources and costs.
Cellulose excipients from India and the United States were assessed for tablet formulation functionality.

Purpose of the Study:

To determine physical and technological characteristics of celluloses from different origins.
To ascertain the functionality of these celluloses as tablet excipients.

Main Methods:

Evaluated surrogate functionality properties including particle morphology and size distribution.
Assessed compactibility, ejection pressure, and disintegration of pure excipients and compressed tablets.

Main Results:

Innovator celluloses (Avicel, Croscarmellose) demonstrated superior compactibility and disintegration compared to generic counterparts (Alfacel, Carmacel).
Avicel showed 26% greater compactibility than Alfacel; Croscarmellose showed 50% greater compactibility than Carmacel.
Avicel tablets disintegrated faster (3.7 min) than Alfacel (28 min), while Carmacel exhibited better disintegration than Croscarmellose.

Conclusions:

Generic celluloses (Alfacel, Carmacel) are satisfactory tablet excipients, despite being inferior in some aspects to innovator brands.
Alfacel and Carmacel possess potential as filler, binder, and disintegrant in tablet design.
Reported differences may be influenced by inter-batch variability and moisture content variations.