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Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Implementing registries and results databases of clinical trials: is there a side effect?
Matthias Dahm1, Paula González, Nicolás Porteiro
1Universitat Rovira i Virgili, Reus, Spain.
Expert Review of Pharmacoeconomics & Outcomes Research
|June 16, 2010
Summary
Mandatory clinical trial registries and results databases aim to increase transparency but may reduce pharmaceutical companies' incentives to conduct clinical trials. Further research is needed to balance transparency goals with research incentives.
Area of Science:
- Health Policy
- Pharmaceutical Research
- Clinical Trial Design
Background:
- Growing debate on clinical trial design, spurred by accusations of selective data disclosure by pharmaceutical firms.
- Calls for increased transparency through mandatory clinical trial registries and results databases are prominent.
Purpose of the Study:
- To analyze the impact of mandatory registries and databases on pharmaceutical firms' incentives to conduct clinical trials.
- To explore the potential trade-offs between transparency and research incentives in clinical trial regulation.
Main Methods:
- Analysis of prior work by the authors on pharmaceutical firm incentives.
- Economic modeling of regulatory effects on clinical trial conduct.
Main Results:
- Mandatory registries and databases can enhance transparency in clinical trials.
- These regulations may inadvertently decrease the incentives for pharmaceutical firms to initiate clinical trials.
Conclusions:
- A trade-off exists between increased transparency and reduced incentives for conducting clinical trials.
- Informed policy decisions require further research into the incentive effects of transparency regulations.
- Balancing competing goals is crucial for effective clinical trial policy.
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