Dialysate and blood temperature during hemodialysis: comparing isothermic dialysis with a single-pass batch system

The Genius is a convenient single-pass batch hemodialysis system. Dialysate is heated during the preparation phase. Once the container is filled at one of the three available starting temperatures, dialysate cools spontaneously. As dialysate temperature plays an important role in hemodynamic stability, knowledge of the instantaneous dialysate temperature is important. We documented the evolution of dialysate temperature during Genius dialysis with dialysate prepared at two different temperatures (low and medium) as well as its effect on blood temperature and hemodynamic stability. Genius dialysis was compared to isothermic dialysis obtained by a module programmed to obtain a constant blood temperature. With Genius, dialysate temperature progressively decreased from 36.3 (low) and 37.6°C (medium) in the beginning to 34.4 and 35.3°C at the end of the session, both following first-order kinetics. During isothermic dialysis, dialysate cooled from 37.3 to 35.4°C, being warmer than with Genius low. Blood temperature decreased during dialysis with Genius low, from 36.4 to 36.2°C, whereas with medium temperature, blood temperature initially rose from 36.4°C at 15 min to 36.5 and 36.6°C at 30 and 60 min, respectively, followed by a decrease from 180 min onward, to 36.4°C at the end. During isothermic dialysis, blood temperature remained stable, as expected. Blood pressure decreased during all three schedules, with the highest value at 15 min during isothermic dialysis, and at the end of the session, the lowest value with isothermic dialysis.