Bladder function of end-stage renal disease patients

Area of Science:

• Urology
• Nephrology
• Transplantation Medicine

Background:

• End-stage renal disease (ESRD) significantly impacts patient health.
• Bladder function in ESRD patients awaiting renal transplantation (RTx) is not fully understood.
• Renal replacement therapy (RRT) duration may influence bladder parameters.

Purpose of the Study:

• To evaluate bladder function in ESRD patients using video H2O cystometry (CM) prior to RTx.
• To identify the prevalence of detrusor overactivity (DO) in this cohort.
• To assess the relationship between RRT duration and cystometric findings.

Main Methods:

• Video H2O cystometry (CM) was performed on 92 ESRD patients (57 male, 35 female; mean age 45.4 years).
• Patients were grouped based on the presence of detrusor overactivity (DO).
• Key parameters recorded included first sensation (FS), maximum cystometric capacity (MC), and compliance; the effect of RRT duration was analyzed.

Main Results:

• 27.2% of patients exhibited DO, a higher prevalence than in the general Japanese population.
• DO prevalence was independent of RRT duration.
• Bladder compliance was maintained in 50 patients; however, FS, MC, and compliance values decreased proportionally with longer RRT duration.

Conclusions:

• ESRD patients awaiting RTx frequently exhibit bladder dysfunction, characterized by low capacity, low compliance, and DO.
• This bladder dysfunction negatively affects patients' quality of life.
• Bladder function and associated symptoms warrant specific attention in the management of patients undergoing RTx.