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Updated: Jun 12, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Structural lung changes, lung function, and non-invasive inflammatory markers in cystic fibrosis
Charlotte M H H T Robroeks1, Marieke H Roozeboom, Pim A de Jong
1Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands. crob@paed.azm.nl
Summary
Cystic fibrosis (CF) patients
Area of Science:
- Pulmonary Medicine
- Biomarkers
- Medical Imaging
Background:
- Cystic fibrosis (CF) lung disease involves chronic inflammation and infections, leading to lung damage and reduced function.
- Non-invasive markers of inflammation are needed for monitoring CF progression.
Purpose of the Study:
- To explore the link between non-invasive inflammatory markers in exhaled breath condensate (EBC) and lung function/structural changes in CF patients.
- To assess correlations between EBC inflammatory markers, lung function tests, and high-resolution computed tomography (HRCT) scores.
Main Methods:
- Evaluated lung function (FVC, TLC) and EBC inflammatory markers (nitric oxide, nitrate, nitrite, 8-isoprostane, hydrogen peroxide) in 34 CF patients.
- Assessed structural lung changes using HRCT with standardized scoring.
- Utilized multiple linear regression to identify predictors of lung function.
Main Results:
- Generally low correlations between EBC markers and lung structure/function.
- CF patients with Pseudomonas infection showed higher EBC nitrite and HRCT scores.
- Hydrogen peroxide, bronchiectasis, and mosaic perfusion predicted FVC; 8-isoprostane, nitrate, hydrogen peroxide, and mucous plugging predicted TLC.
Conclusions:
- Non-invasive EBC inflammatory markers and HRCT imaging together predict lung function in CF.
- Further longitudinal studies are needed to confirm the utility of EBC monitoring for CF patient follow-up.
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