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Cerebrovascular responsiveness to hypercapnia in intracerebral tissue transplants
J Sharkey1, D E McBean, P A Kelly
1Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Scotland, U.K.
Brain Research
|February 22, 1991
Abstract:
Cerebral blood flow was measured using [14C]iodoantipyrine quantitative autoradiography in rats which had previously undergone unilateral ibotenate-induced nucleus basalis lesion followed by intracortical implantation of foetal basal forebrain cell suspensions. Transplants had no effect upon host cortical blood flow, although within the transplant itself, blood flow was significantly lower than the contralateral site. Both the transplant and host cortex exhibited a similar degree of hyperaemia in response to hypercapnia.