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Updated: Jun 12, 2026
Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
Influence of bisphosphonates in orthodontic therapy: Systematic review
Alejandro Iglesias-Linares1, Rosa-María Yáñez-Vico, Enrique Solano-Reina
1School of Dentistry, University of Seville, Spain. aiglesiaslinares@gmail.com
Objective:
The objective of this paper was to analyse the effects of bisphosphonates and their influence on orthodontic therapy.
Data/Sources:
The literature was systematically reviewed using PubMed/Medline, Scopus, Ebsco Host, Scirus and Cochrane databases up to December 31, 2008.
Study Selection:
Articles were independently selected by two different researchers based on previously established inclusion and exclusion criteria, finding a good concordance (kappa index of 0.862). The methodological quality of the reviewed papers was assessed. The search strategy identified 205 titles. Thirteen articles were selected after application of the inclusion/exclusion criteria, and only one of these had a high methodological quality. Bisphosphonate applications in orthodontic therapy were divided between two main groups: tooth movement and skeletal relapse.
Conclusions:
Topical or systemic application of bisphosphonates decreases orthodontic tooth movement and reduces orthodontic tooth movement relapse and skeletal relapse after maxillary expansion or mandibular distraction and similar procedures. Further longer-term studies are required to assess possible adverse effects after bisphosphonate treatment for these purposes.
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