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Updated: Jun 12, 2026

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Structural basis for conservation in the CYP51 family

Galina I Lepesheva1, Michael R Waterman

  • 1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA. galina.i.lepesheva@vanderbilt.edu

Biochimica Et Biophysica Acta
|June 16, 2010
PubMed
Summary

Sterol 14α-demethylases (14DM) are vital CYP51 enzymes found across all life. This review details conserved amino acids and CYP51 variants, aiding the development of targeted inhibitors for microbial infections.

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