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Related Experiment Video

Updated: Jun 12, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Future perspectives in hepatocellular carcinoma.

Marcus A Wörns¹, Peter R Galle

¹I Department of Internal Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55101 Mainz, Germany.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

|June 16, 2010

Summary

Hepatocellular carcinoma (HCC) management has improved with early diagnosis and targeted therapies like sorafenib. Future research aims to personalize HCC treatment based on molecular profiling for better patient outcomes.

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Published on: September 12, 2019

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Last Updated: Jun 12, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Area of Science:

Hepatology
Oncology
Molecular Biology

Background:

Hepatocellular carcinoma (HCC) is a leading cause of cancer death globally.
Late diagnosis and liver cirrhosis limit treatment options for many HCC patients.
Recent advances offer improved surveillance, early detection, and multimodal therapies.

Purpose of the Study:

To review current knowledge on Hepatocellular carcinoma (HCC) management.
To provide insights into future perspectives for HCC treatment.
To highlight progress in multidisciplinary treatment modalities for HCC.

Main Methods:

Review of current literature on Hepatocellular carcinoma (HCC) management.
Analysis of recent advancements in surveillance and diagnosis.
Evaluation of targeted therapy and multimodal treatment approaches.

Main Results:

Significant progress in surveillance and early diagnosis of HCC.
Multikinase inhibitor sorafenib shows promise for advanced and early/intermediate stages.
Understanding molecular hepatocarcinogenesis enables targeted therapy development.

Conclusions:

Multidisciplinary approaches and targeted therapies are improving HCC prognosis.
Personalized treatment strategies based on genomic and proteomic profiling are the future of HCC care.
Continued research into molecular pathways will refine individualized HCC treatment.