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Related Experiment Video

Updated: Jun 12, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Skin coverage in frostbite injuries: experimental study.

Julio Delgado-Martínez¹, Gregorio Martínez-Villén, Jose R Morandeira

¹Mixed Research Unit, University of Zaragoza, Spain; Department of Plastic Surgery, Miguel Servet University Hospital of Zaragoza, Spain. juldelgado@yahoo.com

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS

|June 16, 2010

Summary

For frostbite defects, cutaneous flaps offer superior wound coverage and faster healing compared to dermal grafts or secondary intention healing. This study demonstrates flaps as a more effective treatment for cold injury tissue defects.

Related Experiment Videos

Last Updated: Jun 12, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Area of Science:

Reconstructive surgery
Tissue engineering
Trauma management

Background:

Dermal grafting is a common treatment for cold injury tissue defects.
Local flaps are often displaced by grafting in secondary wound healing.
The efficacy of different treatments for frostbite defects requires further investigation.

Purpose of the Study:

To compare the effectiveness of guided wound healing, dermal grafts, and cutaneous flaps in treating frostbite defects.
To evaluate surface area lacking cutaneous cover at day 7 (SCp7) and healing time (TC).

Main Methods:

A cold injury model was used to create dorsal defects in rabbit legs.
Animals were divided into three groups: secondary intention healing, dermal graft, and flap coverage.
SCp7 and TC were analyzed for each treatment group.

Main Results:

Flap coverage resulted in the smallest SCp7 (62mm2) and shortest healing time (11.6 days).
Dermal grafts showed a larger SCp7 (130mm2) and longer healing time (15.9 days).
Secondary intention healing had the largest SCp7 (225mm2) and longest healing time (20.1 days).

Conclusions:

Cutaneous flaps provide superior skin cover in both quality and quantity compared to grafts.
The independent vascular supply of flaps makes them less dependent on recipient bed characteristics.
Early treatment of frostbite injuries with flaps is feasible due to rapid tissue damage assessment.