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Updated: Jun 12, 2026
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A Nonsequencing Approach for the Rapid Detection of RNA Editing
Published on: April 21, 2022
DARNED: a DAtabase of RNa EDiting in humans
1Biochemistry Department, University College Cork, Ireland.
Bioinformatics (Oxford, England)
|June 16, 2010
Summary
DARNED is a new database centralizing RNA editing data, mapping over 42,000 human RNA editing sites. This resource aids researchers in accessing and analyzing RNA editing information for improved prediction algorithms.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- RNA editing alters nucleotide sequences compared to genomic templates.
- High-throughput sequencing has identified numerous human RNA editing instances.
- Existing RNA editing data is fragmented and difficult to access.
Purpose of the Study:
- To create a centralized database for RNA editing data.
- To provide easy access to comprehensive RNA editing information.
- To support researchers and algorithm developers in the field of RNA editing.
Main Methods:
- Developed DARNED (DAtabase of RNa EDiting) database.
- Mapped RNA editing locations to the human reference genome.
- Integrated data queryable by genomic coordinates, functional RNA regions, and tissue sources.
Main Results:
- Database contains ~42,000 human RNA editing sites, primarily adenosine-to-inosine (A-to-I) substitutions.
- Data includes functional localization (Exons, Introns, CDS, UTRs) and tissue/organ/cell source information.
- Search results provide supporting ESTs, functional localization, and SNP data, with browser integration.
Conclusions:
- DARNED offers centralized access to diverse RNA editing data.
- Facilitates exploration of RNA editing across various genomic contexts and biological sources.
- A valuable resource for RNA editing research and computational tool development.
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