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Updated: Jun 12, 2026

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Published on: December 28, 2013
Hypermetabolism in patients with dementia with Lewy bodies
Nobuhiko Miyazawa1, Toyoaki Shinohara, Takamura Nagasaka
1Department of PET Center of Kofu Neurosurgical Hospital, Kofu, Yamanashi, Japan. nobu_miya9311@yahoo.co.jp
Purpose:
Detection of hyperperfusion by I-123 N-isopropyl-p-iodoamphetamine single photon emission computed tomography can be helpful to diagnose dementia with Lewy bodies (DLB). This study characterized hypermetabolism in DLB.
Materials And Methods:
A total of 22 probable cases of DLB were examined by F-18 2-fluoro-2-deoxy-D-glucose positron emission tomography.
Results:
Hypermetabolism was found in the peri-motor area, basal ganglia, and cerebellum. Eleven patients had hypermetabolism in all 3 areas, 6 in 2 areas, 4 in 1 area, and 1 in no area. Hypermetabolism was most frequent in the cerebellum. Comparison of the 11 patients with hypermetabolism in all 3 areas to the other 11 cases found no significant differences in age (P = 0.2555), sex (P = 0.1889), Mini-Mental State Examination score (P = 0.0897), and Parkinsonism. However, visual hallucinations were significantly more frequent in the patients with hypermetabolism in all 3 areas (P = 0.0018).
Conclusions:
Hypermetabolism is common in patients with DLB and may be related to visual hallucinations.
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